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    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（一）
      Di L, Zhu Y, Jia J et al. Clinical safety of induced CTL infusion through recombinant adeno-associated virus-transfected dendritic cell vaccination in Chinese cancer patients. Clin Transl Oncol. 2012 Sep;14(9):675-81.

    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（二）
      Kaplitt MG, Feigin A, Tang C, et al. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson’s disease: an open label, phase I trial. Lancet. 2007 Jun 23;369(9579):2097-105.

    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（三）
      Jacobson SG, Cideciyan AV, Ratnakaram R, et al. Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol. 2012 Jan;130(1):9-24.

    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（四）
      Muramatsu S, Fujimoto K, Kato S, et al. A phase I study of aromatic L-aminoacid decarboxylase gene therapy for Parkinson’s disease. Mol Ther. 2010Sep;18(9):1731-5.

    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（五）
      Flotte TR, Trapnell BC, Humphries M, et al. Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results. Hum Gene Ther. 2011 Oct;22(10):1239-47. Epub 2011 Aug 24.

    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（六）
      McPhee SW, Janson CG, Li C, et al. Immune responses to AAV in a phase I study for Canavan disease. J Gene Med. 2006 May;8(5):577-88.

    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（七）
      Aitken ML, Moss RB, Waltz DA, et al. A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease. Hum Gene Ther. 2001Oct 10;12(15):1907-16.

    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（八）
      Cideciyan AV, Hauswirth WW, Aleman TS, et al. Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year. Hum Gene Ther. 2009 Sep;20(9):999-1004.

    • 05

      2017-09

      ACTL有效性及AAV安全性临床试验文献（九）
      Simonelli F, Maguire AM, Testa F, et al. Gene therapy for Leber’s congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther. 2010 Mar;18(3):643-50.

    • 05

      2017-09

      ACTL临床前研究文献（一）
      Liu Y, Chiriva-Internati M, Grizzi F, Salati E, Roman JJ, Lim S, Hermonat PL. Rapid induction of cytotoxic T-cell response against cervical cancer cells by human papillomavirus type 16 E6 antigen gene delivery into human dendritic cells by an adeno-associated virus vector. Cancer Gene Ther. 2001 Dec;8(12):948-57.